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Tirzepatide is commonly discussed as a dual GIP and GLP-1 receptor agonist, while Retatrutide is discussed as a triple GIP, GLP-1 and glucagon receptor agonist

There are also less common but important risks including gallbladder disease, pancreatitis, dehydration from vomiting or diarrhea, worsening reflux or gastroparesis symptoms

Stabilization is not passive delay

This reduces the amount of glucose that enters the blood, especially after eating

GIP appears to counteract some of the nausea-inducing effects of GLP-1

Croatian researchers first isolated and characterized this peptide in 1993 from a larger protein found naturally in human gastric juice